| Up regulated genes |
| BIC |
- Genlocus for miRNA-155- is regulated by PKC and NFKB after BCR stimulation [36]
|
| SGK1 |
- a Serine/Threonine kinase, important for cellular stress response- regulated GSK3 and binds IKK (NFkB Pathway) |
| SRGN |
- is associated with Granzyme/Perforine complex, perhaps a mediator of apoptosisi- regulates secretion of TNFα |
| VASP |
- a adaptor protein, involved in intracellular signal transduction, that regulates interaction between integrines and intercellular matrix- is regulated by PKA and PKG |
| ZFP36L1 |
- a Zinc finger transcription factor, activated by cellular stess- is a early response gene |
| Down regulated genes |
| APBB1IP |
- plays role in signaltransduction of Ras to remodel the actin cyto skeleton- interacts with VASP- plays role in TCR activation |
| C5orf13 |
- open reading frame without known funtion |
| DAPP1 |
- adaptor protein, regulates JNK, RAC1 and MAPK signaling cascades |
| ETS1 |
- a transcription factor, plays role in stem cell development, cellular senescence and death- associated with BCR stimulation [23]- regulates CDKN1A (p21, cell cycle inhibitor), MDM2 (p53 antagonist) and MMPs |
| GLRX |
- a thioltransferase, important in NFkB signaling pathway |
| RNF144B |
- a ring finger protein; E3 ubiquitin ligase, avoiding spontaneous apoptosis [47] (BRDC2 = RNF144B)- is regulated by p53- ubiquitinates CDKN1A |
| SSBP3 |
- a single strand binding protein, transcription regulator |
| VPREB3 |
- associated with µ chain in pre-B cell receptor synthesis, supposed to be involved in its transport |
