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. 2011 Feb 18;6(2):e17311. doi: 10.1371/journal.pone.0017311

Figure 3. Miniature IPSCs in PND21-25 rats are not affected by bath application of NMDA or D-APV.

Figure 3

A: representative traces under control conditions (left) and after bath application of 30 µM NMDA (right). No changes in mIPSCs were observed. B: bar graphs showing that bath application of NMDA did not have any significant effect on mIPSC amplitude (left) or frequency (right). C: representative traces under control conditions (left) and after bath application of 50 µM APV (right). D: bar graphs showing that bath application of APV did not affect the frequency or the amplitude of mIPSCs. This suggests that presynaptic NMDA receptors do not modulate GABA release in PND 21-25 rats.