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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Brain Res. 2010 Sep 21;1380:120–137. doi: 10.1016/j.brainres.2010.09.026

Figure 2. Sociability in Shank1 mice.

Figure 2

Adult sociability, assayed in an automated photocell-equipped three-chambered arena, revealed unpredicted confounds. A) None of the Shank1 genotypes displayed normal sociability, defined as more time in the side chamber with the novel mouse than in the side chamber with the novel object. In contrast, control mice from the hybrid background B6/Jae, used to breed the Shank1 mutation, displayed normal sociability for time in the chamber containing the novel mouse versus time in the chamber containing the novel object. * p < 0.05. B) Shank1 -/- and B6/Jae displayed significantly more time spent sniffing the novel mouse than time spent sniffing the novel object. C) No genotype differences were seen in the number of entries into the either the left or right side chambers. D) No innate chamber side bias was present in any group during the 10 minute habituation phase before the start of the sociability test. N=15 +/+; N =8 +/-; N=17 -/-; N=12 B6/Jae.