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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: Clin Cancer Res. 2010 Nov 18;17(4):771–782. doi: 10.1158/1078-0432.CCR-10-2444

Figure 5.

Figure 5

CNT-sCpG eradicates established gliomas. Mice bearing four day-old i.c. GL261.luc gliomas (n=6) were given a single i.t. injection of PBS (control), free sCpG (5µg/10µl PBS), blank CNT (2.5 µg) mixed with free sCpG (CNT + sCpG; 5µg CpG/10µl PBS), or sCpG conjugated to CNT (CNT-sCpG; 2.5 µg CNT-5 µg sCpG/10 µl PBS). A, Intracranial tumor burden was assessed by biophotonic imaging. B, Kaplan-Meier analysis demonstrates improved survival of mice treated with a single injection of CNT-sCpG.