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. Author manuscript; available in PMC: 2012 Feb 24.
Published in final edited form as: J Med Chem. 2011 Jan 19;54(4):1010–1021. doi: 10.1021/jm101250y

Figure 3.

Figure 3

Chemical structures and antiprion activity of analogs 38 and 39, in which ring fusion enforces a co-planar A/B-ring conformation. Activities of the corresponding unconstrained analogs 25 and 14 are shown for comparison.