Skip to main content
. Author manuscript; available in PMC: 2012 Feb 24.
Published in final edited form as: J Med Chem. 2011 Jan 19;54(4):1010–1021. doi: 10.1021/jm101250y

Figure 4.

Figure 4

Chemical structures and antiprion activity of analogs with modified A–B ring linkages (46) or B–C ring linkages (47–50). The introduction of an amide linkage was better tolerated at the A–B ring connection (46) than at the B–C ring connection (47 and 48). Alkylation or acylation of the amino B–C ring linkage was tolerated (17 vs 49 and 50) demonstrating that a hydrogen bond donor is not required in this position.