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. Author manuscript; available in PMC: 2012 Feb 24.
Published in final edited form as: J Med Chem. 2011 Jan 19;54(4):1010–1021. doi: 10.1021/jm101250y

Scheme 1.a.

Scheme 1.a

aHantzsch-type synthesis of 2-aminothiazole analogs from amines via thiourea intermediates. Reagents and conditions: (a) PhSCN, acetone, reflux; (b) NaOH, MeOH, reflux; (c) bromoacetophenone, EtOH, reflux.