Fig. 6.
Compound CW modulates Aβ42 formation at lower concentrations in primary neurons than in the H4 cell line. Different concentrations of the non-steroidal anti-inflammatory drug CW were administered in cultures of H4 cells overexpressing human APPK595N/M596L and primary telencephalic chicken neurons. Cell supernatants were assessed for Aβ content by an immunosorbent assay. a In the H4 cell line, Aβ42 levels started to diminish at a concentration of 50 μM. b In primary telencephalic neurons, Aβ42 levels started to decrease already at a concentration of 5 μM. The blue bar indicates toxic concentrations. Graphs represent the individual Aβ content in percent of vehicle-treated cultures as mean ± standard error of mean