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. 2011 Jan 21;30(4):706–718. doi: 10.1038/emboj.2010.355

Figure 8.

Figure 8

The OIG-4 interacts physically with L-AChRs and LEV-10 and stabilizes the L-AChR/LEV-10 interaction. (A) Detection of the UNC-29 L-AChR subunit after immunoprecipitation of GFP-OIG-4 using anti-GFP antibodies from WT and transgenic lines expressing GFP-OIG-4. UNC-29 no longer co-precipitates when GFP-OIG-4 is expressed in a lev-10(kr26) null mutant background (n=3 independent experiments). (B) LEV-10 co-immunoprecipitates with OIG-4-GFP as above. The interaction is lost in an unc-29(x29) null mutant background (n=3 independent experiments). (C) LEV-10 is co-immunoprecipitated with UNC-63-YFP using anti-GFP antibodies. Co-precipitation is lost in an oig-4(kr39) mutant background (n=3 independent experiments).