Figure 4.
Salmon calcitonin release from P(MAA-co-NVP)-based microparticle (90-150 μm particle size) formulations. The particles were prepared with 1% EGDMA as a crosslinking agent. Release was performed in 1× PBS (pH 7.4) and in an alkaline borate buffer (pH 10). Results are presented of release from formulations prepared with 1:1 monomer molar feed ratio and released in 1× PBS (◆) or in alkaline borate (◊). Results are also presented of release from formulations prepared with 4:1 monomer molar feed ratio and released in 1× PBS (■) or in alkaline borate (□) (n=3 ± SD).