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. Author manuscript; available in PMC: 2011 Feb 19.
Published in final edited form as: J Biol Chem. 2003 Aug 27;278(45):43991–44000. doi: 10.1074/jbc.M306360200

Fig. 5. Effect of glycosylation on functional association of SERT proteins.

Fig. 5

Either CHO cells (A and C) or Lec4 cells (B) were transfected with different amounts of Res-FLAG and Sens-Myc cDNAs and assayed for serotonin uptake activity. Squares represent serotonin uptake rates; circles represent rates after treatment with 0.25 mM MTSEA for 10 min. Three lines were plotted according to predictions of the amount of activity remaining after MTSEA treatment. The dotted lines are the activity expected if no interaction occurred between the resistant and sensitive forms and if the amount of inactivation was equal to the amount of activity contributed by Sens-Myc. The solid lines represent the predicted activity if SERT was a dimer and if modification of both subunits was required for inactivation of activity in that dimer. The dashed lines represent the expected activity if modification of one subunit in a dimer inactivated all the activity of that dimer.

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