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. 2010 Dec 8;21(3):330–348. doi: 10.1111/j.1750-3639.2010.00457.x

Figure 2.

Figure 2

Loss of substantia nigra (SN) tyrosine hydroxylase (TH)‐positive neurons in lipopolysaccharide (LPS)‐treated mice. TH immunohistochemistry of the SN revealed a progressive loss of TH immunoreactive fibers and cell bodies in the SNpc and SNpr in LPS‐treated mice. In particular, it was obvious that LPS lead to lower numbers of TH cell bodies and neurites in the lateral portion of the SN. This appeared to be a progressive loss, as it was observable more in the 12‐month wild‐type (WT) and Gdnf +/− mice, and was found to be more severe in the Gdnf reduced mice than in WT mice. However, a loss of TH cell bodies could be seen already in the 3‐week‐old LPS‐treated Gdnf +/− mice (see panel 1), with fewer neurites and atrophied cell bodies apparent. Scale bar in lower right represents 500 microns.