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. 2010 Dec 8;21(3):330–348. doi: 10.1111/j.1750-3639.2010.00457.x

Figure 3.

Figure 3

Lower densities of tyrosine hydroxylase (TH) staining in 12‐month‐old Gdnf+/− subjects. (A) TH densitometry in the striatum, (B) TH‐immunoreactive (TH‐ir) cell counts in the substantia nigra (SN) and (C) TH‐ir cell sizes in the SN. Densitometry (A) of striatal TH staining revealed a significant loss of TH‐ir at 12 months of age in the Gdnf +/− mice, regardless of treatment. Lipopolysaccharide (LPS) treatment gave rise to a significant age‐related decrease in TH cell numbers (B) and cell size (C) in Gdnf +/− compared with wild‐type (WT) LPS‐treated mice. There was an overall age effect [(2,48); F = 3.920; P = 0.0265) with a trend toward a genotype–treatment interaction [(1,48); F = 3.388; P = 0.0719], but no interaction between treatment and age.