Table 4.
Mean cognitive composite scores and MMSE by rs11136000, rs3851179, and rs6656401 genotypes
| SNP (gene) | Genotypes | Mean cognitive composite score (SD) |
Mean MMSE (SD) |
Mean cognitive composite score (SD) |
Mean MMSE (SD) | ||
|---|---|---|---|---|---|---|---|
| Females | Males | Females | Males | ||||
| rs11136000 (CLU) | CC | 0.02 (0.16) | 21.64 (0.26) | −0.15 (0.19) | 0.42 (0.28) | 21.32 (0.31) | 22.39 (0.47) |
| CT | 0.53 (0.14) | 22.17 (0.23) | 0.55 (0.17) | 0.54 (0.26) | 22.03 (0.27) | 22.48 (0.44) | |
| TT | 0.60 (0.25) | 22.16 (0.42) | 0.65 (0.30) | 0.47 (0.47) | 22.09 (0.49) | 22.33 (0.83) | |
| rs3851179 (PICALM) | GG | 0.15 (0.16) | 21.71 (0.26) | 0.28 (0.19) | −0.14 (0.29) | 21.86 (0.29) | 21.37 (0.54) |
| AG | 0.49 (0.14) | 22.13 (0.23) | 0.31 (0.16) | 0.90 (0.27) | 21.71 (0.28) | 23.12 (0.41) | |
| AA | 0.17 (0.27) | 21.62 (0.44) | −0.09 (0.34) | 0.78 (0.45) | 21.24 (0.56) | 22.51 (0.70) | |
| rs6656401 (CR1) | GG | 0.40 (0.12) | 21.71 (0.26) | 0.30 (0.14) | 0.65 (0.22) | 21.88 (0.23) | 22.62 (0.35) |
| AG | 0.15 (0.18) | 22.13 (0.23) | 0.04 (0.22) | 0.38 (0.32) | 21.52 (0.35) | 22.30 (0.58) | |
| AA | 0.66 (0.58) | 21.62 (0.44) | 1.82 (0.63) | −1.51 (0.94) | 21.24 (0.56) | 19.64 (1.73) | |
Key: MMSE, Mini Mental State Examination; SNP, single nucleotide polymorphism.