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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Pharmacol Res. 2010 Dec 14;63(4):341–351. doi: 10.1016/j.phrs.2010.12.002

Table 1.

Plasma and brain drug levels 2 and 24 hours after i.p. administration of selected taxanes and epothilones.

Compound 2 hours (5 mg/kg) 24 hours (10 mg/kg)
Plasma Brain B/P1 Plasma Brain B/P
ng/ml SD ng/g SD ng/ml SD ng/g SD
Paclitaxel 1286 341 85 56 0.07
CNDR-3 15 3 BLD2 -- NC3
CNDR-29 389 109 BLD -- NC
CNDR-66 14 4 109 21 7.6 BLD -- 64 11 NC
CNDR-85 5 2 236 21 52.9 1.7 0.4 259 26 157
CNDR-86 20 4 86 21 4.3 0.5 0.4 88 19 118
CNDR-87 1.4 0.6 71 18 52 BLD -- 28 1.9 NC
CNDR-88 12 5 30 10 2.6 6.1 2.9 45 19 7.3
CNDR-89 6.8 1.9 24 10 3.5 BLD -- 13 0.5 NC
CNDR-90 319 110 142 1.4 0.4 41 16 107 24 2.6
1

B/P = Brain-to-Plasma ratio;

2

BLD = Below Limit of Detection;

3

NC = Not Calculated