. Author manuscript; available in PMC: 2012 Apr 1.

Published in final edited form as: Pharmacol Res. 2010 Dec 14;63(4):341–351. doi: 10.1016/j.phrs.2010.12.002

Table 2.

Evaluation of epothilone MT stabilizers for predicted membrane permeability and efflux ratios in MDCK-MDR cells.

Compound	Papp (A-B) (10⁻⁶ cm/s)	Papp (B-A) (10⁻⁶ cm/s)	Efflux Ratio (B-A)/(A-B)
CNDR-66	30	46.8	1.6
CNDR-85	8.2	49.8	6.1
CNDR-86	4.4	62.0	14
CNDR-87	11.9	54.8	4.6
CNDR-88	0.8	58.6	73
CNDR-89	2.3	63	28