Table 2.
Nectin 4 Enzyme-Linked Immunosorbent Assay Analysis of Patient Serum Samples
| Diagnosis | No. Positive |
Mean Nectin 4 (ng/mL) |
Mean CA125 (U/mL) |
Specificity Sensitivity (%) |
PPV (%) |
NPV (%) |
(%) |
|---|---|---|---|---|---|---|---|
| Serous (n = 51) | 3.699 (0–31.0) | 2,246.2 (6–22,780) | |||||
| Nectin 4 | 27 | 53 | — | 77 | — | ||
| CA125 | 47 | 92 | — | 60 | — | ||
| Nectin 4 and CA125 | 27 | 53 | — | 82 | — | ||
| Clear cell (n = 14) | 0.944 (0–4.23) | 222.6 (13-1,504) | |||||
| Nectin 4 | 4 | 29 | — | 33 | — | ||
| CA125 | 11 | 79 | — | 26 | — | ||
| Nectin 4 and CA125 | 3 | 21 | — | 33 | — | ||
| LMP (n = 18) | 0 (0-0) | 264.6 (6.6-1,539) | |||||
| Nectin 4 | 0 | — | 100 | — | 43 | ||
| CA125 | 14 | — | 22 | — | 50 | ||
| Nectin 4 and CA125 | 0 | — | 100 | — | 43 | ||
| Benign (n = 51) | 0.629 (0–10.83) | 151.4 (4-1,984) | |||||
| Nectin 4 | 8 | — | 84 | — | 64 | ||
| CA125 | 31 | — | 39 | — | 83 | ||
| Nectin 4 and CA125 | 6 | — | 88 | — | 65 |
LMP, low malignant potential; NPV, negative predictive value; PPV, positive predictive value.