Table 1.
Drugs with anti-endothelin effects as a possible approach for glaucoma therapy
| Human studies | Animal studies | ||||
|---|---|---|---|---|---|
| Drug classes | IOP | Blood flow | IOP | Blood flow | RGC |
| ET receptor blocker | |||||
| ETA blocker | |||||
| BQ-123 | Ø | ↑ | ↓ | ↑ | |
| ETB blocker | |||||
| BQ-788 | + | ||||
| ETA/B blocker | |||||
| Bosentan | Ø | ↑ | |||
| PG F analogues | |||||
| Travoprost | ↓ | ↑ | ↓ | ↑ | |
| Latanoprost | ↓ | ↑ | ↓ | ↑ | + |
| Bimatoprost | ↓ | ↑ | ↓ | ||
| Tafluprost | ↓ | ↓ | ↑ | + | |
| Unoprostone | ↓ | ↑ | ↓ | ↑ | + |
(↑) increase, (↓) decrease, (+) positive effect, (Ø) no effect.
ET, endothelin, IOP, intraocular pressure; PG, prostaglandin, RGC, retinal ganglion cell.