Table 1.
Number of animals used in each experiment
| Parameters | Plac + Veh + Nx | Plac + AS30 + Nx | Morph + Veh + Nx | Morph + AS30 + Nx | Total n |
|---|---|---|---|---|---|
| Number of rats at the beginning of the experiment = 33 | 7 | 7 | 9 | 10 | |
| Somatic signs of opiate withdrawal | 6 | 5 | 8 | 9 | 28 |
| ACTH levels | 5 | 6 | 9 | 10 | 30 |
| Corticosterone levels | 5 | 6 | 8 | 8 | 27 |
| MHPG, NA and NA turnover | 4 | 6 | 5 | 10 | 25 |
| TH pSer31-IR | 6 | 6 | 5 | 5 | 22 |
| TH pSer40-IR | 5 | 6 | 4 | 6 | 21 |
| CRF2-IR | 7 | 6 | 13 |
ACTH, adrenocorticotropic hormone; NA, noradrenaline; MHPG, 3-methoxy-4-hydroxyphenylethylen glycol; TH, tyrosine hydroxylase; Veh, vehicle; Nx, naloxone; Plac, placebo; Morph, morphine.