Figure 2.

Graphs and representative photomicrographs illustrating the effect of reinstatement and SB-334867 on Fos expression in the pre-limbic (PrL), orbitofrontal (OFC), piriform cortex and nucleus accumbens core. Reinstatement significantly increased the number of Fos-positive neurones in the PrL, OFC, piriform cortex and nucleus accumbens core in both the immediate and delayed reinstatement groups. In the PrL and OFC, SB-334867 significantly reduced this increase in the immediate and delayed group, while the effect was only observed in the immediate reinstatement group in the accumbens core, and the delayed reinstatement group in the piriform cortex. *P < 0.05 versus vehicle; ^∧P < 0.05 versus immediate reinstatement, three-way analysis of variance with planned comparisons. #P < 0.05 versus extinction, two-way anova with planned comparisons. Ext, extinction; Veh, vehicle; SB, SB-334867. All scale bars = 100 µm.