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. 2011 Feb;162(4):890–896. doi: 10.1111/j.1476-5381.2010.01092.x

Figure 3.

Figure 3

Role of the cAMP/PKA pathway in regulation of rapid delayed rectifier K+ current (IKr). Left-hand column of each pair shows IKr tail current amplitudes measured in control (no drug, n= 13), following superfusion with forskolin (3 µM, n= 6), and after internal application of cAMP (250 µM, n= 9), 8-Br-cAMP (250 µM, n= 8), 6-bnz-cAMP (100 µM, n= 8), 8-pCPT-2'-O-Me-cAMP (100 µM, n= 6) and Rp-8-Br-cAMP (100 µM, n= 6). Right-hand column of each pair indicates IKr tails obtained following superfusion with 100 nM ISO. Data are means ± SEM. *Indicates significant (P < 0.05) differences from the control (no drug) IKr amplitude, determined using unpaired t-test. +Denotes ISO-induced differences from the respective pre-ISO values, determined using paired t-test. ISO, isoprenaline; PKA, protein kinase.