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. 2011 Feb;162(4):917–928. doi: 10.1111/j.1476-5381.2010.01098.x

Figure 3.

Figure 3

Treatment with NDP-α-MSH reduced TNF-α mRNA expression in the liver (A) and lung (B) of MODS mice. Pretreatment with the melanocortin MC4 receptor antagonist HS024 and the nicotinic acetylcholine receptor antagonist chlorisondamine prevented the effect of NDP-α-MSH. Values are means ± SEM for 6 mice per group at day 7 after zymosan. NDP-α-MSH: 340 µg·kg−1 i.p. for 7 days after zymosan; saline: 1 mL·kg−1 i.p. for 7 days after zymosan; HS024: 130 µg·kg−1 i.p. 1 min before each NDP-α-MSH or saline administration; chlorisondamine: 0.25 mg·kg−1 s.c. 1 min before each NDP-α-MSH or saline administration. *P < 0.01 vs. MODS + saline; #P < 0.01 vs. MODS + NDP-α-MSH (Student-Newman-Keuls test).