Table 1.

NDP-α-MSH reduced histological damage in MODS mice; HS024 and chlorisondamine prevented the protective effect of NDP-α-MSH

Parameter	Sham MODS + saline	Sham MODS + NDP-α-MSH	MODS + saline	MODS + NDP-α-MSH	MODS + HS024 + NDP-α-MSH	MODS + chlorisondamine + NDP-α-MSH	MODS + HS024 + saline	MODS + chlorisondamine + saline
Liver histological score at day 7 after zymosan
Inflammatory infiltrate	0	0	2.67 ± 0.21	1.00 ± 0.26*	2.50 ± 0.22#	2.50 ± 0.34#	3.00 ± 0.00#	3.00 ± 0.00#
Steatosis	0	0	2.50 ± 0.34	0.83 ± 0.17*	2.33 ± 0.33#	2.33 ± 0.42#	2.83 ± 0.17#	2.67 ± 0.33#
Necrosis	0	0	2.83 ± 0.17	0.33 ± 0.21*	2.50 ± 0.34#	2.33 ± 0.21#	3.00 ± 0.00#	3.00 ± 0.00#
Ballooning degeneration	0	0	2.83 ± 0.17	0.33 ± 0.33*	2.67 ± 0.21#	2.67 ± 0.33#	3.00 ± 0.00#	2.83 ± 0.17#
Lung histological score at day 7 after zymosan
Inflammatory infiltrate	0	0	2.67 ± 0.21	1.17 ± 0.17*	2.50 ± 0.15#	2.50 ± 0.22#	2.83 ± 0.17#	3.00 ± 0.00#
Vascular congestion	0	0	2.83 ± 0.17	0.33 ± 0.21*	2.33 ± 0.21#	2.33 ± 0.33#	3.00 ± 0.00#	2.83 ± 0.17#
Interstitial oedema	0	0	2.50 ± 0.22	0.17 ± 0.17*	2.50 ± 0.34#	2.67 ± 0.33#	2.83 ± 0.17#	2.67 ± 0.21#

NDP-α-MSH: 340 µg·kg⁻¹ i.p. for 7 days; saline: 1 mL·kg⁻¹ i.p. for 7 days; HS024: 130 µg·kg⁻¹ i.p 1 min before each NDP-α-MSH or saline administration; chlorisondamine: 0.25 mg·kg⁻¹ s.c. 1 min before each.

NDP-α-MSH or saline administration. Values shown are mean ± SEM for 6 mice per group.

^*P < 0.01 versus MODS + saline;

^#P < 0.01 versus MODS + NDP-α-MSH (Dunn test).