Skip to main content
. 2011 Feb;162(4):961–973. doi: 10.1111/j.1476-5381.2010.01102.x

Figure 1.

Figure 1

Effect of intrathecal injection of orexin A (OX-A) on mean arterial pressure (MAP), heart rate (HR) and splanchnic sympathetic nerve activity (sSNA). (A) Representative trace of data from a recording of blood pressure (BP), HR and sSNA (arbitrary unit, a.u.) before and after injection of phosphate-buffered saline (PBS) or OX-A (20 nmol). Rectified and integrated sSNA (black) is superimposed over raw sSNA (grey). MAP (black) is superimposed over BP (grey). (B) Comparison of peak cardiovascular effects produced by PBS, OX-A (1, 5, 10 and 20 nmol) or SB334867 (200 nmol) + OX-A (20 nmol). Peak effects are shown as absolute (BP, HR) or percentage (sSNA) change from their respective basal values. (C) Grouped time course effects of PBS (black) or OX-A (20 nmol) (red) on MAP, HR and sSNA. Values are expressed as mean ± standard error. Number of animals are shown in parentheses. bpm, beats per minute; ns, non-significant; ***P < 0.001, **P < 0.01, *P < 0.05 compared with PBS [except SB 334867 (200 nmol) + OX-A (20 nmol) that was compared with OX-A (20 nmol)].