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. Author manuscript; available in PMC: 2011 Feb 21.
Published in final edited form as: Psychopharmacology (Berl). 2010 Aug 10;212(4):485–499. doi: 10.1007/s00213-010-1970-0

Figure 1.

Figure 1

Figure 1

Effect of the α1-adrenergic receptor antagonist prazosin (0.25–1 mg/kg) on the elevations in brain reward thresholds associated with mecamylamine-precipitated nicotine withdrawal (A; saline, n = 8; nicotine, n = 9) and response latencies (B). Asterisks (** P<0.01) indicate elevations in brain reward thresholds compared to those of the corresponding saline-treated control group. Plus signs (+ P<0.05) indicate lower brain reward thresholds compared to those of rats chronically treated with nicotine and acutely treated with mecamylamine and vehicle. Data are expressed as means ± SEM.