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. 2010 Nov 23;50(3):611–619. doi: 10.1093/rheumatology/keq307

Table 4.

Multivariable model examining predictors of osteocalcin and TRAP

Parameter β-coefficient (95% CI) P-value
Multivariable model for osteocalcina
    SLEDAI, units −0.40 (−1.18, 0.37) 0.31
    Age, year −2.59 (−3.95, −1.22) <0.001*
    Weight, kg −0.25 (−0.47, −0.02) 0.03*
    Prednisone, mg/kg/day −29.7 (−43.2, −16.3) <0.001*
    25-OH vitamin D, ng/ml −0.21 (−0.58, 0.17) 0.19
    1,25-OH2 vitamin D, ng/ml 0.06 (−0.14, 0.26) 0.54
    TRAP, U/l 3.16 (0.97, 5.4) 0.005*
    Male gender 15.5 (5.77, 25.1) 0.002*
Multivariable model TRAPb
    SLEDAI, units −0.06 (−0.11, −0.002) 0.04*
    Age, year −0.12 (−0.22, −0.02) 0.02*
    Height, cm −0.02 (−0.05, 0.01) 0.28
    Weight, kg 0.003 (−0.02, 0.02) 0.78
    25-OH vitamin D, ng/ml 0.02 (−0.008, 0.05) 0.16
    Osteocalcin, ng/ml 0.02 (0.0001, 0.03) 0.049*
    NTxc 0.002 (−0.001, 0.005) 0.23

aMultivariable model examining predictors of osteocalcin shows that SLEDAI is not significantly associated with bone formation after controlling for confounders. Model-adjusted R2 = 0.37 (n = 130 observations, 77 subjects). bMultivariable model examining predictors of TRAP shows that SLEDAI is negatively associated with bone resorption after controlling for confounders. Model-adjusted R2 = 0.29 (n = 132 observations, 81 subjects). cBCE/mM creatinine. *P < 0.05.