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Reason for discontinuation
| High dose (n=223) |
Low dose (n=222) |
Total (n=445) |
|
|---|---|---|---|
| Treatment completed per protocol | 52(25) | 49(25) | 101(25) |
| Disease progression | 33(16) | 35(18) | 68(17) |
| Adverse events or complications | 56(27) | 37(19) | 93(23) |
| Death on study | 8(4) | 5(3) | 13(3) |
| Patient withdrawal or refusal | 11(5) | 10(5) | 21(5) |
| Alternative therapy | 30(14) | 40(21) | 70(17) |
| Other complicating disease | 2(1) | 1(<1) | 3(1) |
| Other | 17(8) | 16(8) | 33(8) |
Data are number (%).
