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. 2011 Jan 27;46(2):170–176. doi: 10.1093/alcalc/agq097

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© The Author 2011. Published by Oxford University Press on behalf of the Medical Council on Alcohol.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Hazard ratio over time [HR(t)] based on Cox regression with time-dependent covariates (HR(t) = e^{(−6.51 Group−0.02 Age} ⁺ ^{0.13 Group} ^× ^Age ⁺ ^{0.35 Group} ^× ^Time ⁺ ^{0.00 Age} ^× ^Time ⁻ ^{0.01 Age} ^× ^Group ^× ^Time)). Age was treated as a continuous variable. The plot is based on pre-specified values for treatment group condition and age (30 and 50 years), and the interaction between treatment condition and age.