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. 2010 Dec 8;22(2):217–224. doi: 10.1089/hum.2010.072

FIG. 1.

FIG. 1.

Vector structure and integrant localization. (A) The ΔΦMscvCD18 vector used in this study is shown with the MSCV promoter and canine CD18 gene indicated. The deleted foamy virus (ΔFV) backbone has deletions in the U3 region of the LTR (ΔU3) and in each of the remnants of the three major viral genes (Δgag, Δpol, and Δenv). (B) The vector proviruses found in or near cancer-related genes are shown with the arrow above each gene indicating provirus location and direction of vector transcription. Cellular genes and dog chromosomal positions are shown with transcription units in thick lines and exons as boxes (translated exons are taller boxes). Transcription start sites are indicated by arrows below each gene. Proto-oncogenes (MECOM, MTCP1, and PAX5) and tumor suppressor genes (NBN and ABI2) are pictured. Note that the BRCC3 gene in the FD3-1 integrant map is not a cancer-related gene.