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. 2011 Feb 3;12:5. doi: 10.1186/1471-2091-12-5

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Copyright ©2011 Krasowski et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PXR concentration-response curves. Ligand activation of PXRs from different species. A) T-0901317 activates human PXR (hPXR) and chicken PXR (chPXR) but not Tetraodon PXR (tnPXR) or zebrafish PXR (zfPXR). B) The primary conjugated bile acid taurochenodeoxycholic acid (TCDCA) activates hPXR and tnPXR but not chPXR or zfPXR. C) The steroid 5β-pregnane-3,20-dione (5β-pregnanedione) activates all four PXRs shown. D) Nifedipine activates hPXR, chPXR, and zfPXR, but not tnPXR. The ordinate indicates fold induction compared to vehicle control in luciferase-based assay. Note that the scale of the ordinate is different in A) through D).