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. 2011 Feb 4;12(1):21. doi: 10.1186/1465-9921-12-21

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Copyright ©2011 Yu and Hales; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of electroporation of bone marrow cells with CXCR4 shRNA on hypoxia-induced pulmonary hypertension and vascular remodeling in rats: (A) Percent wall thickness. *p < 0.05 as compared with normoxia and hypoxic controls. # p < 0.05 as compared with normoxia and BMC+CXCR4. $p < 0.05 as compared with normoxia. (B) Body weight change. # p < 0.05 as compared with normoxia. *p < 0.05 as compared with normoxia and hypoxic controls. (C) hematocrit. *p < 0.05 as compared with normoxia control. n = 5 rats for each group. BMC = transplantation of bone marrow cells without shRNA, BMC+S-RNA = transplantation of bone marrow cells with scrambled shRNA, BMC+ CXCR4 = transplantation of bone marrow cells with CXCR4 shRNA.