Table II. HD5 and HD6 enhance entry of virus with various envelopesa.
| Envelope | HD5 | HD6 |
|---|---|---|
| Vesicular stomatitis virus | 2.8 ± 0.7 fold | 23 ± 5.8 |
| Murine leukemia virus | 6.8 ± 0.1 | 99 ± 7.7 |
| HIVHxB2 (B), X4 | 2.7 ± 0.6 | 8.4 ± 1.2 |
| HIVRB231 (B), R5 | 17.8 ± 4.6 | 41 ± 6.9 |
| HIVJR-FL (B), R5 | 41 ± 0.4 | 64 ± 13.9 |
a
Pseudotyped luciferase reporter viruses with different envelopes were incubated with defensins at 10 μg/ml at 37°C for 1 h. Viral entry was then determined as described in Fig. 1 in HeLa-CD4-CCR5 cells containing endogenous CXCR4. Results are expressed as fold increase compared to untreated samples in triplicate and represent three independent experiments (mean ± S.D).