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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Neuroendocrinol. 2011 Mar;23(3):269–281. doi: 10.1111/j.1365-2826.2010.02105.x

Fig. 1.

Fig. 1

TIMP-2 KO mice gain more weight than WT mice regardless of diet. Both sexes of two-month-old TIMP-2 KO mice fed a chow (A) or HFD (B) for 3 months gained significantly more weight than WT mice (as determined by weight slope; chow: M p = 0.03, F p = 0.04; HFD: M p = 0.0001, F p = 0.0003). (C-F) Examination of average daily food consumption revealed that chow- (C, E) and HFD-fed (D, F) TIMP-2 KO mice failed to modify food intake despite increased body weight. Decreased food consumption in chow-fed mice after day 68 was due to overnight starvation and insulin tolerance testing (data not shown). Data are mean ± SEM. n = 8 per sex, genotype, and diet.