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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Curr Opin Immunol. 2011 Jan 3;23(1):41–45. doi: 10.1016/j.coi.2010.10.004

Fig. 1.

Fig. 1

Sialoside-based pattern recognition discriminates infections from aseptic tissue injuries by two possible mechanisms. First, CD24 forms trimolecular complex with DAMPs and Siglec G that inhibits activation of TLR/NLR. Second, pathogen-encoded sialidases prevent CD24 from interacting with Siglec G. As a result, DAMPs and PAMPs become indistinguishable during infection.