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A model for the pathogenesis of spontaneous lupus nephritis based on studies in mice. Abbreviations: SLE, systemic lupus erythematosus; dsDNA, double-stranded DNA; MCP1, monocyte chemoattractant protein 1; RANTES. Regulated upon Activation, Normal T-cell Expressed, and Secreted; TGFβ, transforming growth factor β; GMCSF, granulocyte-macrophage colony stimulating factor; IL, interleukin; IFN-gamma, interferon gamma.
