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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Jan 15;1812(4):507–513. doi: 10.1016/j.bbadis.2011.01.007

Figure 1. Amyloid beta treatment reduces mitochondrial movements.

Figure 1

Axons from mature hippocampal neurons transfected with DsRed-mito and GFP, then treated for 24 hours with vehicle, Aβ, or reverse peptide were imaged to evaluate mitochondrial movements. Total proportion of moving mitochondria, proportion of mitochondria moving anterograde, and proportion of mitochondria moving retrograde were calculated (A). The speed of motion was also calculated for all moving mitochondria (B). Calculations were based on analysis of kymographs. Representative kymographs are shown for the three experimental groups (C). N= 4 independent cultures. * p < 0.05 compared to vehicle treated, and statistical variation is shown as mean±SE.