Skip to main content
. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Jan 15;1812(4):507–513. doi: 10.1016/j.bbadis.2011.01.007

Figure 5. Drp1 distribution relocates from areas of active neurite outgrowth to neuritic processes after amyloid beta treatment.

Figure 5

Hippocampal neurons treated with PBS vehicle or Aβ were immunostained for Drp1, mitochondrial-encoded protein, Cyt. B and nuclear marker, DAPI. Vehicle treated cells (upper panel) showed intense immunoreactivities of Drp1 (A), Cyt. B (B), DAPI (C) and merged (D) in neurite growth cones (white arrows). Drp1 is colocalized with Cyt. B (D) (white arrows). After Aβ treatment (lower panel), Drp1 staining is reduced (E), and Drp1 is colocalzed with mitochondria in merged image (H).