Table 2.
Comparisons of COPD patients with respect to FXIa and/or TF activity
| Parameter | FXIa and/or TF activity | ||
|---|---|---|---|
| Present (n=10) | Absent (n=50) | p-value | |
| Age, years | 74.5 (20) | 63 (16) | 0.082 |
| Sex, M/F | 10/0 | 45/5 | 0.578 |
| BMI, kg/m2 | 23.7 (6.0) | 24.7 (5.1) | 0.396 |
| Current smokers, n (%) | 6 (60) | 16 (32) | 0.149 |
| Cigarettes, pack years | 36.5 (25) | 30 (22.5) | 0.943 |
| Spirometry | |||
| FEV1, % predicted | 51.5 (19) | 58 (18) | 0.293 |
| FEV1/FVC, % predicted | 64 (12) | 59.5 (16) | 0.234 |
| VC, % predicted | 66 (15) | 80 (17.2) | 0.004 |
| Echocardiography | |||
| EF, % | 60 (10) | 61 (14) | 0.331 |
| RVSP, mm Hg | 47 (15) | 38 (12) | 0.023 |
| Laboratory tests | |||
| Glucose, mM | 4.90 (0.30) | 4.65 (1.10) | 0.393 |
| Creatinine, µM | 78.5 (19) | 87 (21) | 0.525 |
| Fibrinogen, g/l | 5.58 (2.01) | 3.97 (2.47) | 0.0007 |
| CRP, mg/l | 14.75 (1.20) | 1.88 (2.95) | <10−6 |
| IL-6, pg/ml | 8.14 (4.74) | 2.45 (2.24) | 0.000003 |
| TNFα, pg/ml | 2.41 (2.48) | 1.88 (0.67) | 0.243 |
| MMP-9, ng/ml | 606 (457) | 477 (273) | 0.150 |
| F1.2, pM | 398 (216) | 192 (42) | <10−6 |
| FXIa, pM | 39.5 (81.0) | ND | - |
Results are expressed as median (interquartile range). COPD, chronic obstructive pulmonary disease; FXIa, coagulation factor XIa; TF, tissue factor; ND, not detected; other abbreviations, see table 1. FXIa was detected in 9 patients, and quantifiable in 8 subjects.