Triciribine abrogates KGF-enhanced IL-1-induced IL-8 secretion in Caco-2 cells. Caco-2 cells (5 × 104 cells/well) were cultured in 24-well plates for 24 h before adding triciribine to a final concentration of 0.1 or 1.0 μM. Then, after 30 min, rhHGF at 100 ng/ml, IL-1 at 0.5 ng/ml, or both were added as indicated. After 24 h, the supernatants were collected and the total IL-8 concentrations determined. The graphs represent the mean ± SEM of three experiments and the asterisk indicates a significance difference from all other values (p<0.03).