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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Transfus Apher Sci. 2011 Jan 28;44(1):81–91. doi: 10.1016/j.transci.2010.12.013

Figure 1. Duplication of the RH gene and loss of the RHD gene.

Figure 1

The ancestral configuration is shown as represented by the RH gene locus in mouse. The single RH gene is in close proximity to the three genes SMP1, P29-associated protein (P), and NPD014 (N). A duplication event introduced a second RH gene in reverse orientation between N and SMP1. At the two break points in front and behind the RHD gene, DNA segments of approximately 9,000 base pairs (bp) occur. Both DNA segments are flanking the RHD gene and dubbed ”upstream Rhesus box“ and ”downstream Rhesus box“. In the RHD positive haplotype, the RHD gene may have been lost by a recombination event (see Figure 3).