Table 1.

Representative molecular changes in RHD alleles expressing distinct phenotypes of the D antigen

classification of antigen variation	D antigen Phenotype	molecular basis		representative example		novel Rhesus antigen
		protein variation	Mechanisms	RHD allele	trivial name
partial D	qualitative change	amino acid substitution on the RBC surface	missense mutation	RHD(G355S)	DNB	Unknown
		protein segment exchange on the RBC surface	gene conversion (hybrid protein)	RHD-CE(3–6)-D	DVI type 3	BARC
weak D	quantitative change	amino acid substitution in the membrane or intracellularly	missense mutation	RHD(V270G)	weak D type 1	Unknown
DEL	major quantitative	grossly reduced translation or	missense mutation	RHD(M295I) in CDe	not applicable	unknown
	change	protein expression	mutation at splice site	RHD(K409K)	not applicable	unknown
D negative	D negative	lack of protein expression	gene deletion	RHD-Deletion	D negative	unknown
			nonsense mutation	RHD(Y330X)	not applicable	unknown
			Frame shift mutation	RHD(488del4)	not applicable	unknown
			modifying gene	defect of RHAG gene	Rhnull	unknown
		protein segment exchange on the RBC surface	gene conversion (hybrid protein)	RHD-CE(3–7)-D	Cdes	Unknown
antithetical antigens of the RhCE protein	expression of antigen E or antigen e	amino acid substitution on the RBC surface	missense mutation at amino acid position 226 in RHCE	RHCE allele: Ala226 coding antigen e Pro226 coding antigen E	not applicable	E versus e