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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Curr Opin Immunol. 2010 Nov 29;23(1):21–28. doi: 10.1016/j.coi.2010.11.004

Figure 1. Innate immune detection of HIV PAMPs.

Figure 1

Model of the HIV life cycle and known interactions between HIV and innate immunity. HIV RNA and nascent capsid protein (CA) can be detected in dendritic cells (left) by TLR7 and an unknown sensor, respectively. HIV DNA can be detected in CD4 T cells and macrophages (right) by an unknown cytsolic DNA sensor that signals through STING and TBK1. The host factor TREX1 inhibits innate immune detection of HIV DNA by metabolizing non-productive RT products. Detection of HIV by any of these three innate immune pathways activates IFN genes.