Table II. Intracellular cAMP levels after SAMe or MTA supplementation.
cAMP intracellular levels were measured as described in Material and Methods from primary hepatocytes in culture, 1h and 12h after the first MTA supplementation, and 1h after the second MTA supplementation. Each data represents the mean ± SD of at least quadruplicate experiments (*p<0.05; vs. control).
| cAMP (fmol/1.5 million cells) | 1h | 12h | 13h |
|---|---|---|---|
| CONTROL | 498 ± 22.5 | 523.9 ± 26.1 | 481.0 ± 16 |
| MTA 500 μM | 1253.9 ± 59.7* | 1162.5 ± 95.9* | 1767.7 ± 132* |
| SAMe 4mM | 589.2 ± 32.5 | 1287.3 ± 58.4* | 1112.4 ± 74.8* |