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Differences in chemical shift between 37°C and 70°C plotted on the native NMR structure of HEWL (PDB entry 1E8L (36)). Blue: Stable parts of the structure where the 1HN chemical shift differences between 37°C and 70°C (Table S1) are small (i.e., > −0.07 ppm for three or more consecutive residues). Gray parts are largely unfolded at high temperature, as suggested by the larger random deviations. Red: Clearly observed native long-range NOEs. Light blue: Disulphide bonds.
