Table 8.
Epitopes associated with modulation of allergic disease.
| Epitope name | Epitope sequence | Host | Response | Allergy model |
|---|---|---|---|---|
| Cyn d 1 (127–146) | KAGELTLQFRRVKCKYPSGT | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (19–38) | LEAKATFYGSNPRGAAPDDH | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (154–173) | KGSNDHYLALLVKYAAGDGN | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (136–155) | RRVKCKYPSGTKITFHIEKG | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (28–47) | SNPRGAAPDDHGGACGYKDV | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (82–101) | VECSGEPVLVKITDKNYEHI | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (227–246) | VIPANWKPDTVYTSKLQFGA | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (91–110) | VKITDKNYEHIAAYHFDLSG | Human | T cell, DCP | Bermuda grass pollen |
| Cyn d 1 (73–92) | CYEIKCKEPVECSGEPVLVK | Human | T cell, DCP | Bermuda grass pollen |
| Fel d 1 IPC-2 | KALPVVLENARILKNCVDAKMTEEDKE | Human | T cell, LSC, NSC | Cat allergy |
| Fel d 1 IPC-1 | KRDVDLFLTGTPDEYVEQVAQYKALPV | Human | T cell, LSC, NSC | Cat allergy |
| peptide 4 (P93-110) | TKCYKLEHPVTGCGERTE | Human | T cell, CLPR | Honey bee sting |
| peptide 1 (P81-98) | YFVGKMYFNLIDTKCYKL | Human | T cell, CLPR | Honey bee sting |
| Bet v 1 | SKEMGETLLRAVESYLLAHSD | Mouse | B cell, AWI | Birch pollen |
| Der p 1 111–139 | FGISNYCQIYPPNANKIREALAQPQRYCR | Mouse | T cell, DTP | European HDM |
| Der p 1 113–127 | ISNYCQIYPPNANKI | Mouse | T cell, DTP | European HDM |
| Der p I (101–154) | QSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAVIIGIKDLDAFRHYD | Mouse | T cell, DTP | European HDM |
| Der p 1 110–131 | RFGISNYCQIYPPNANKIREAL | Mouse | T cell, DTP | European HDM |
| Der p I 114–129 | SNYCQIYPPNANKIR | Mouse | B cell, DTH | European HDM |
| Der p 2 87–129 | DIKYTWNVPKIAPKSENVVVTVKVMGDDGVLACAIATHAKIRD | Mouse | B cell, BPR, AWI | European HDM |
| Der p I (98–140) | AREQSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAV | Mouse | T cell, DTP | European HDM |
| Api m 4 7–19 | KVLTTGLPALISW | Mouse | B cell, IgG1 | Honey bee sting |
| Dol m 5 176–195 | IEDNWYTHYLVCNYGPGGND | Mouse | B cell, IgG1 | Hornet sting |
| Dol m 5 41–60 | KNEILKRHNDFRQNVAKGLE | Mouse | T cell, DTP | Hornet sting |
| Dol m 5 141–160 | NYKVGLQNSNFRKVGHYTQM | Mouse | T cell, DTP | Hornet sting |
| Cry j 2 247–258 | AEVSYVHVNGAK | Mouse | B cell, CSI | Japanese cedar pollen |
| Cry j 2 P2 246–259 | RAEVSYVHVNGAKF | Mouse | T cell, NS | Japanese cedar pollen |
| Ole 1 109–130 | TVNGTTRTVNPLGFFKKEALPK | Mouse | B cell, AWI | Olive tree pollen |
| Phl p 5 peptide | YAATVATAPEVKYTVFETALKKAI | Mouse | B cell, AWI | Timothy grass pollen |
| Phl p 1 peptide | LRSAGELELQFRRVKCKYPEG | Mouse | B cell, AWI | Timothy grass pollen |
| Bet v 1/Phl p 1/Phl p 5 hybrid | MGETLLRAVESYAGELELQFRRVKCKYTVATAPEVKYTVFETALK | Mouse | B cell, AWI | Tree/Grass pollen |
| PI-1 IgECHε2 (109-117) | LYCFIYGHI | Mouse | T cell, PCA | Mouse |
| nOVA 173–196 | VLVNAIVFKGLWEKAFKDEDTQAM | Rat | B cell, PCA | Chicken Egg |
| OVA (257–264) | SIINFEKL | Mouse | T cell, AWI | Asthma |
| OVA (323–339) | ISQAVHAAHAEINEAGR | Mouse | T cell, AWI | Asthma |
HDM: house dust mite. Mouse strains consisted of BALB/c and C57BL/6. Rats were Norway strain. AWI: airway inflammation (histology). NS: nasal symptoms (sneezing and rubbing). CSI: cytokine suppression of allergen-IgE production. BPR: bronchopulmonary resistance. DTH: delayed type hypersensitivity. LSC: lung score. NSC: nasal score. CLPR: cutaneous late-phase reaction. DTP: decrease allergen-specific T cell proliferation. DCP: decreased allergen-specific cytokine production.