Table 1.
Physiological effects of the human FGF gene.
| Gene | Location | Receptor | Therapeutic application | Ref. |
|---|---|---|---|---|
| FGF1 | 5q31.3 | FGFR 1b, 1c, 2b, 2c, 3b, 3c, 4 | Cardiovascular disease | [32] |
| FGF2 | 4q27 | FGFR 1b, 1c, 2c, 3c, 4 | Cardiovascular disease, cancer | [33–36] |
| FGF3 | 11q13.3 | FGFR 1b, 2b | Not established | |
| FGF4 | 11q13.3 | FGFR 1c, 2c, 3c, 4 | Stable angina | [37] |
| FGF5 | 4q21.21 | FGFR 1c | Hair growth | [38] |
| FGF6 | 12p13.32 | FGFR 1c, 2c, 4 | Not established | |
| FGF7 | 15q21.2 | FGFR 2b | Oral mucositis | [39] |
| FGF8 | 10q24.32 | FGFR 3c, 4 | Not established | |
| FGF9 | 13q12.11 | FGFR 2c, 3b, 3c, 4 | Not established | |
| FGF10 | 5p12 | FGFR 1b, 2b | Not established | |
| FGF11 | 17p13.1 | Intracytoplasmic | Not established | |
| FGF12 | 3q28 | Not identified | Not established | |
| FGF13 | Xq26.3 | Not identified | Not established | |
| FGF14 | 13q33.1 | Not identified | Not established | |
| FGF16 | Xq21.1 | FGFR 4 | Not established | |
| FGF17 | 8p21.3 | FGFR 2c, 3c, 4 | Not established | |
| FGF18 | 5q35.1 | FGFR 2c, 3c, 4 | Osteoarthritis, cartilage | [40] |
| FGF19 | 11q13.3 | FGFR 4 | Diabetes | [41] |
| FGF20 | 8p22 | Not identified | Parkinson's disease | [42] |
| FGF21 | 19q13.32 | Not identified | Diabetes | [43] |
| FGF22 | 19p13.3 | FGFR 2b | Not established | |
| FGF23 | 12p13.32 | FGFR 3c | Hypophosplataemia | [44] |