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Aβ42 immunoblot of the hippocampal CA1 field of apoE4, apoE3, and apoE-deficient mice. The mice were treated for 10 days with thiorphan after which they were killed and their hippocampus was extracted and immunoblotted with the anti-Aβ42 Ab 266 as described in “Materials and Methods.” Membrane bound NP40 extractable Aβ42 (apparent molecular weight 4.5 kD) is shown in the upper panels whereas the corresponding PBS extractable soluble Aβ42 is shown in the lower panels.
