Table 1.
Expression of common markers and translocations in histological subtypes of gastrointestinal lymphomas
| Type | CD5 | CD10 | CD19 | CD20 | CD22 | CD23 | CD43 | CD79a | CD3 | CD7 | CD4 | CD8 | CD30 | CD15 | CD45RO | Additional features |
| Diffuse large B-cell lymphoma | -(+) | -(+) | + | + | + | - | - | + | - | - | - | - | -(+) | - | -(+) | Bcl-6+(-), Bcl-2+(-), t (14;18), t (3;14), t (8;14) |
| MALT lymphoma | - | - | + | + | + | - | -(+) | + | - | - | - | - | - | - | -(+) | t (11;18), t (14;18), t (1;14), t (3;14) |
| Follicular lymphoma | - | +(-) | + | + | + | -(+) | - | + | - | - | - | - | -(+) | - | - | Bcl-2+, Bcl-6+, t (14;18) |
| Burkitt lymphoma | - | + | + | + | + | -(+) | + | + | - | - | - | - | - | - | - | C-myc, t (8;14) |
| Mantle cell lymphoma | + | - | + | + | + | - | + | + | - | - | - | - | - | - | - | Cyclin D1+, t (11;14) |
| Peripheral T-cell lymphoma-unspecified | +(-) | -(+) | - | - | - | - | +(-) | - | +(-) | -(+) | +(-) | -(+) | -(+) | -(+) | -(+) | - |
| Extranodal NK/T cell lymphoma | -(+) | - | - | - | - | - | + | - | -(+) | +(-) | -(+) | - | -(+) | -(+) | - | EBV+, gains of 2q, 15q, 17q, 22q, losses of 6q, 8p, 11q, 12q, 13q |
| EATL | - | - | - | - | - | - | +/- | - | + | + | -(+) | +(-) | +(-) | - | +(-) | TIA1+, gains of 1q, 5q, 7q, 9q, losses of 8p, 9p, 13q |
| Hodgkin disease | +(-) | - | - | -(+) | - | - | - | -(+) | +(-) | -(+) | - | - | +(-) | +(-) | -(+) | Variable |
+: ≥ 90% positive; +(-): > 50% positive; -(+): < 50% positive; -: < 10% positive cases. MALT: Mucosa-associated lymphoid tissue; EATL: Enteropathy-associated T-cell lymphoma; EBV: Epstein-Barr virus.