Table 4.
Precore and core promoter mutations in patients with hepatitis B e antigen (+), before and after hepatitis B e antigen seroconversion n (%)
| All |
Group 1 |
Group 2 |
Group 3 |
Group 2+3 |
P-value |
||||
| HBeAg(+), HBeAb(-) | HBeAg(-), HBeAb(+) | HBeAg(-), HBeAb(-) | HBeAg(-) | 1 vs 2 | 1 vs 3 | 2 vs 3 | 1 vs (2+3) | ||
| T1762/A17641 | |||||||||
| Absent | 90 (50.3) | 42 (59.2) | 38 (44.2) | 10 (45.5) | 48 (44.4) | 0.062 | 0.258 | 0.915 | 0.054 |
| Present | 89 (49.7) | 29 (40.8) | 48 (55.8) | 12 (54.5) | 60 (55.6) | ||||
| A18962 | |||||||||
| Absent | 65 (61.3) | 48 (100.0)3 | 15 (34.9) | 2 (13.3) | 17 (29.3) | < 0.001 | < 0.001 | 0.114 | < 0.001 |
| Present | 41 (38.7) | 0 (0.0) | 28 (65.1) | 13 (87.7) | 41 (70.7) | ||||
| A18992 | |||||||||
| Absent | 81 (76.4) | 43 (89.6) | 27 (62.8) | 11 (73.3) | 38 (65.5) | 0.003 | 0.034 | 0.116 | 0.004 |
| Present | 25 (23.6) | 5 (10.4) | 16 (37.2) | 4 (26.7) | 20 (34.5) | ||||
| T1762/A1764 and A18962 | |||||||||
| Absent | 88 (83.0) | 48 (100.0) | 31 (72.1) | 9 (60.0) | 40 (68.9) | < 0.001 | < 0.001 | 0.383 | < 0.001 |
| Present | 18 (17.0) | 0 (0.0) | 12 (27.9) | 6 (40.0) | 18 (31.0) | ||||
| T1762/A1764 or A18962 | |||||||||
| Absent | 33 (31.1) | 31 (64.6) | 2 (4.7) | 0 (0.0) | 2 (1.9)4 | < 0.001 | < 0.001 | 0.395 | < 0.001 |
| Present | 73 (68.9) | 17 (35.4) | 41 (95.3) | 15 (100.0) | 56 (98.1) | ||||
1
Total samples n = 179; Hepatitis B e antigen (HBeAg) (+) and hepatitis B e antibody (HBeAb) (-) n = 71; HBeAg(-) and HBeAb(+), n = 86; HBeAg(-) and HBeAb(-), n = 22;
2
Total samples n = 106; HBeAg(+) and HBeAb(-) n = 48; HBeAg(-) and HBeAb(+), n = 43; HBeAg(-) and HBeAb(-), n = 15;
3
Three samples had a mixed population of precore stop codon mutation (A1896) and its wild type (G1896);
4
Two samples with a mixed population of basal core promoter mutation (T1762/A1764) and its wild type (A1762/G1764).