Table 2.
Distribution of N-acetyltransferase 2 polymorphism and the risk of cancer
| Genetic polymorphism NAT2a | Cancer, n (%) | Control, n (%) | P | OR (95% CI) |
| All | 147 | 212 | ||
| Mx/Mx | 88 (59.8) | 110 (51.9) | 0.19 | 1 |
| W/Mx | 44 (30.0) | 83 (39.1) | 0.66 (0.42-1.05) | |
| W/W | 15 (10.2) | 19 (8.9) | 0.99 (0.47-2.05) | |
| Slow | 88 (59.8) | 110 (51.9) | 0.17 | 1.38 (0-2.12) |
| Fast | 59 (40.1) | 102 (48.1) | ||
| Female | 76 | 127 | ||
| Mx/Mx | 42 (55.2) | 58 (45.6) | 0.07 | 1 |
| W/Mx | 23 (30.2) | 58 (45.6) | 0.55 (0.29-1.02) | |
| W/W | 11 (14.4) | 11 (8.6) | 1.38 (0.55-3.48) | |
| Slow | 42 (55.2) | 58 (45.6) | 0.24 | 1.47 (0.83-2.60) |
| Fast | 34 (44.7) | 69 (54.3) | ||
| Male | 71 | 85 | ||
| Mx/Mx | 46 (64.8) | 52 (61.1) | 0.67 | 1 |
| W/Mx | 21 (29.5) | 25 (29.4) | 0.95 (0.47-1.92) | |
| W/W | 4 (5.6) | 8 (9.4) | 0.57 (0.16-2.00) | |
| Slow | 46 (64.7) | 52 (61.1) | 0.76 | 0.86 (0.45-1.65) |
| Fast | 25 (35.2) | 33 (38.9) |
a
Homozygous individuals with genotype W/W, and heterozygote W/Mx, are grouped into fast acetylation phenotype, while homozygous Mx/Mx are grouped in slow acetylators. The percentages of data are in parentheses. NAT2: N-acetyltransferase 2; OR: Odds ratio; 95% CI: Confidence interval.